Waikerie is a rural town in the Riverland region of South Australia on the south bank of the Murray River. At the 2016 census, Waikerie had a population of 2,684. The Sturt Highway passes to the south of the town at the top of the cliffs. There is a cable ferry crossing the river to provide vehicle access from the north side of the river. Waikerie is known for citrus growing, along with stone fruit and grapes.